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01 giugno 2020
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DERIVATIZATION

Systematic chemical and/or enzymatic modification of heparin and related glycosaminoglycans is a valuable strategy for structure-activity studies as well as for obtaining novel molecules endowed with better binding properties towards proteins associated with different biological activities. Derivatization, which can be performed regiospecifically, is also a tool for improvement of pharmacokinetic properties.


a. Low molecular weight heparins and heparin oligosaccharides
Publication number*:278, 277,  273, 260, 247, 244, 240, 235, 222, 217, 197, 195, 193, 189, 188, 168, 166, 163, 127, 121, 59, 57, 56, 48, 42, 41, 40, 37, 28, 27

b. Heparin and dermatan sulfate derivatives
Publication number*: 255, 254, 251, 249, 246, 240, 238, 237, 236, 232, 231, 226, 214, 209, 207, 204, 198, 194, 185, 180, 154, 1487, 133, 130, 124, 123, 122, 120, 109, 108, 104, 72, 59, 51, 46

c. Regioselective sulfation of galactosaminoglycans
Publication number*: 207, 185, 87, 72

d. “Semibiotechnological” glycosaminoglycans
Publication number*: 248, 229, 205, 190, 185, 128, 114, 113


   *see publication list