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01 giugno 2020
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Heparin

Heparin is a sulfated polysaccharide of animal origin widely used in the anticoagulant and antithrombotic therapy. Low-molecular weight heparins and non-anticoagulant heparin derivatives are also promising candidate drugs against cancer and inflammation. Though deceptively simple, the structure of heparin is complex. Unravelling features associated with its different biological activities with the eventual aim of dissecting them and generating more potent and more specific drugs requires convergent use of chemical and enzymatic cleavage and advanced spectroscopic methods.


a. Analytical profiling and physico-chemical properties
Publication number*: 276, 272, 266, 260, 259, 256, 250, 247, 244, 243, 229, 227, 225, 222, 211, 192, 189, 170, 168, 165, 137, 133, 132, 125, 119, 110, 100, 96, 93, 88, 85, 74, 73, 64, 63, 61, 58, 45, 40, 35, 30, 29, 28, 27, 25, 24, 23, 22, 21, 11, 10, 5
 
b. Structure and molecular conformation
Publication number*:267, 265, 251, 246, 245, 242, 237, 236, 235, 232, 224, 223, 214, 213, 211, 210, 204, 201, 199, 198, 195, 190, 188, 187, 180, 178, 163, 155, 154, 148, 138, 137, 128, 126, 125, 123, 121, 119,115,  114, 113, 109, 106, 104, 103, 101, 92, 86, 83,82, 81, 80,62, 60, 50, 49, 46, 44, 42, 41, 37, 34, 28, 20, 18, 16, 15, 14, 12, 7, 6, 4

c. Protein binding
Publication number*: 274, 269, 255, 254, 249, 246, 245, 242, 240,237, 236, 235, 232, 230,226, 224, 223, 217, 216, 214, 213, 211, 210, 208, 204, 201, 199, 198, 191, 189, 188, 187, 178, 171, 163, 156, 141, 140, 128, 126, 120, 118, 114, 107, 99, 94, 62, 60, 51, 37,28

d. Anticoagulant and antithrombotic heparin species
Publication number*: 251, 242, 238, 237, 223, 222, 217, 216, 210, 208, 194, 191, 178, 148, 139, 127, 82, 74, 59, 57, 56, 48, 45, 42, 37, 35, 28, 27, 17

e. Non-anticoagulant heparins as potential anticancer agents
Publication number*: 270, 255, 254, 249, 246, 245, 237, 236, 232, 231, 230, 226, 224, 218, 214, 210, 204, 201, 199, 198, 195, 187, 130, 120

f. Pharmacokinetics and metabolism
Publication number*: 209, 112, 110, 109, 93, 26, 19, 7

* see publication list