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28 ottobre 2020
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NMR Selected Publications

Recent selected publications:

Characterizing the Microstructure of Heparin and Heparan Sulfate using N-sulfoglucosamine 1H and 15N NMR Chemical Shift Analysis. Langeslay, D.J., Beecher, C.N., Naggi, A., Guerrini, M., Torri, G. and Larive C.K. Anal Chem.2013 85, 1247-1255.

An unusual antithrombin-binding heparin octasaccharide with an additional 3-O-sulfated glucosamine in the active pentasaccharide sequence. Guerrini M., Elli S., Mourier P., Rudd T.R., Gaudesi D., Casu B., Boudier C., Torri G., Viskov C. Biochem. J. 2013, 449, 343-351


How To Find a Needle (or Anything Else) in a Haystack: Two-Dimensional Correlation Spectroscopy-Filtering with Iterative Random Sampling Applied to Pharmaceutical Heparin. Rudd T.R., Macchi E., Gardini C., Muzi L., Guerrini M., Yates E.A., and Torri G.. Anal Chem. 2012, 84, 6841-6847.

Construction and use of a library of bona fide heparins employing 1H NMR and multivariate analysis. Rudd TR, Gaudesi D, Skidmore MA, Ferro M, Guerrini M, Mulloy B, Torri G, Yates EA. Analyst. 2011 Apr 7;136(7):1380-9. Epub 2011 Jan 31.

The conformation and structure of GAGs: Recent progress and perspectives. T.R. Rudd, M.A. Skidmore, Guerrini M., Hricovini M., Powell A.K., Siligardi G. and Yates E.A. Curr. Op. Struct. Biol. 2010, 20:1-8.

Effects on molecular conformation and anticoagulant activities of 1,6-anhydrosugars at the reducing terminal of antithrombin-binding octasaccharides isolated from low-molecular-weight heparin enoxaparin. Guerrini M., Elli S., Gaudesi D., Torri G., Casu B., Mourier P., Herman F., Boudier C., Lorenz M. and Viskov C.. J. Med. Chem. 2010 DOI: 10.1021/jm100771s

Ortogonal analytical approches to detect potential contaminants in Heparin Guerrini M., Zhang Z., Shriver Z., Masuko S., Torri G., Naggi A., Langer R., Casu B., Linhardt R., Sasisekharan R.  Proc. Natl Acad Sci,  6;106:16956-16961 (2009)


Structural features of low molecular weight heparins affecting their affinity to antithrombin. A. Bisio, D. Vecchietti, L. Citterio, M. Guerrini, R. Raman, S. Bertini, G. Eisele, A. Naggi, R. Sasisekharan, G. Torri. Thromb Haemost; 102: 865-873 (2009).


Oversulfated chondroitinsulfate is a contaminant in heparin associated with adverse clinical events. M. Guerrini, D. Beccati, Z. Shriver, A. Naggi, K. Viswanathan, A. Bisio, I. Capila, J.C. Lansing, S. Guglieri, B. Fraser, A. Al-Hakim, N.S. Gunay, Z. Zhang, L. Robinson, L. Buhse, M. Nasr, J. Woodcock, R. Langer, G. Venkataraman, R.J. Linhardt, B. Casu, G. Torri, R. Sasisekharan. Nature Biotechnol.,  (April 23, 2008) Epub ahead of print


Antithrombin-binding octasaccharides and role of extensions of the active pentasaccharide sequence in the specificity and strength of interaction. Evidence for very high affinity induced by an unusual glucuronic acid residue. Guerrini M, Guglieri S, Casu B, Torri G, Mourier P, Boudier C, Viskov C. J Biol Chem.,; 26:  26662-26675 (2008).


Minimum FGF2 binding structural requirements of heparin and heparan sulfate oligosaccharides as determined by NMR spectroscopy. Guglieri S, Hricovíni M, Raman R, Polito L, Torri G, Casu B, Sasisekharan R, Guerrini M. Biochemistry, 2008;  47(52):13862-13869



Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives. T.R. Rudd, M.A. Skidmore, S.E. Guimond, R. Duchesne, M. Guerrini, G. Torri, A. Naggi, C. Cosentino, A. Brown, D. Clarke, J.E. Turnbull, D.G. Fernig, E.A. Yates. Glycobiology,17, 983-993 (2007).


Conformational transitions induced in heparin oligosaccharides by binding with antithrombin III. M. Guerrini, S. Guglieri, D. Beccati, G. Torri, C. Viskov, P. Mourier. Biochem. J., 15, 191-198 (2006).


Structure of two glucans and a galactomannan from the lichen Umbilicaria mammulata. E.R. Carbonero, F.R. Smiderle, A.H.P. Gracher, G.G. Mellinger, G. Torri, T. Ahti, P.A.J. Gorin, M. Iacomini. Carbohydr. Polymers, 63, 13-18 (2006).